Sensorimotor and cognitive cerebellar connectivity and brain damage in early multiple sclerosis: is there a link?


  • Sensorimotor and cognitive domains modify their cerebellar functional connectivity in response to brain structural damage, even in the absence of disability.

Why this matters

  • The relationship between altered cerebellar functional connectivity and brain structural damage in multiple sclerosis has yet to be elucidated; this is the first study of functional connectivity alterations of cerebellar motor and cognitive domains, and their relationship with brain structural damage in cases without disability.

  • These important findings further our understanding of the clinical role of cerebellar functional connectivity alterations and whether these changes underlie a preserved clinical status despite brain structural damage; such information would ultimately support development of targeted therapies in early disease stages.