Neurite orientation dispersion and density imaging detects hippocampal abnormalities in temporal lobe epilepsy

Takeaway

  • Diffusion-magnetic resonance imaging metrics identify hippocampal microstructural alterations in temporal lobe epilepsy.

Why this matters?

  • Detection of hippocampal alterations in temporal lobe epilepsy is a key stage in diagnosis and therapy decision making; diffusion-magnetic resonance imaging techniques are a promising tool in evaluating microstructural abnormalities, but their use is not validated.

  • This is the first study to focus on magnetic resonance imaging-segmented hippocampi of people with temporal lobe epilepsy with and without hippocampal sclerosis in post-surgical samples. The findings further our understanding of the hippocampal microstructure in situ and support the use of these imaging techniques in clinical practice.