Closed-Loop Digital Neurotherapeutics for Cognitive Enhancement

Importance of cognitive control

“Cognitive control” refers to a collection of mental functions that enable us to manage the barrage of sensory inputs that we encounter in the world and allow us to engage in complex, goal-directed behavior.1 A growing body of research supports the idea that inefficient regulation of cognitive control processes can lead to significant impairments in cognition, social conduct, and affect regulation and plays an important role in a wide range of mental illnesses: attention-deficit/hyperactivity disorder (ADHD), post-traumatic stress disorder, major depressive disorder, traumatic brain injury, obsessive compulsive disorder, and substance dependence disorders.2-6 Therefore, developing targeted interventions to remediate cognitive and functional deficits in diverse populations with neurological or psychiatric disease, as well as to enhance these abilities in healthy individuals, is of paramount importance.